A single exposure to morphine induces long-lasting hyporeactivity of rat caudate putamen dopaminergic nerve terminals.


The long-lasting effects of exposure to drugs of abuse on the brain is a central theme in drug addiction research. This study was designed to evaluate whether enduring neurochemical adaptations within caudate putamen can be evoked by a single injection of a high dose of morphine. Rats were pretreated once with 10 mg/kg morphine. Seven days later the effect… (More)


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