A single dose and long lasting vaccine against pandemic influenza through the controlled release of a heterospecies tandem M2 sequence embedded within detoxified bacterial outer membrane vesicles.

@article{Watkins2017ASD,
  title={A single dose and long lasting vaccine against pandemic influenza through the controlled release of a heterospecies tandem M2 sequence embedded within detoxified bacterial outer membrane vesicles.},
  author={H. Watkins and Catalina L Pagan and Hannah R Childs and S. Posada and Annie Chau and J. R{\'i}os and C. Guarino and M. DeLisa and G. Whittaker and D. Putnam},
  journal={Vaccine},
  year={2017},
  volume={35 40},
  pages={
          5373-5380
        }
}
  • H. Watkins, Catalina L Pagan, +7 authors D. Putnam
  • Published 2017
  • Biology, Medicine
  • Vaccine
  • The influenza A virus undergoes genetic drift and shift, leaving the general population susceptible to emerging pandemic strains, despite seasonal flu vaccination. Here we describe a single dose influenza vaccine derived from recombinant outer membrane vesicles (rOMVs) that display an antigen-mapped heterospecies tandem sequence of the M2 protein from the influenza A virus, released over 30days from poly(lactic-co-glycolide) (PLGA) microparticles. Four weeks post vaccination, BALB/c mice… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.
    • 8
    • PDF
    M2e-based universal influenza A vaccine.
    • 247
    Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection.
    • 23
    • PDF
    Delivery of foreign antigens by engineered outer membrane vesicle vaccines
    • 175
    • PDF