A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism.

@article{Kim2004ASC,
  title={A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism.},
  author={Joseph A. Kim and Kelly A Pollak and Gregory O Hjelmstad and Howard L Fields},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 15},
  pages={5664-9}
}
Repeated exposure to drugs of abuse produces forms of experience-dependent plasticity including behavioral sensitization. Although a single exposure to many addicting substances elicits locomotor sensitization, there is little information regarding the motivational effects of such single exposures. This study demonstrates that a single cocaine exposure… CONTINUE READING