A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

@article{Cooper1985ASC,
  title={A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.},
  author={Thomas A. Cooper and C. P. Ordahl},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 20},
  pages={11140-8}
}
A single cardiac troponin T gene generates two mRNA products by developmentally regulated alternate splicing. Nucleotide sequence of the entire 18 exon gene and both representative cDNAs demonstrate that the two mRNAs differ by the presence or absence of a single internal coding exon. Both mRNA products appear to be generated from a single primary transcript; however, one mRNA splice product predominates in early embryonic cardiac muscle while the other vastly predominates in adult cardiac… CONTINUE READING
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