A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungs.

@article{Tsoukias2001AST,
  title={A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungs.},
  author={Nikolaos M. Tsoukias and H W Shin and Archie F. Wilson and Steven George},
  journal={Journal of applied physiology},
  year={2001},
  volume={91 1},
  pages={477-87}
}
Current techniques to estimate nitric oxide (NO) production and elimination in the lungs are inherently nonspecific or are cumbersome to perform (multiple-breathing maneuvers). We present a new technique capable of estimating key flow-independent parameters characteristic of NO exchange in the lungs: 1) the steady-state alveolar concentration (C(alv,ss)), 2) the maximum flux of NO from the airways (J(NO,max)), and 3) the diffusing capacity of NO in the airways (D(NO,air)). Importantly, the… CONTINUE READING

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