A single bone marrow-derived stromal cell type supports the in vitro growth of early lymphoid and myeloid cells

@article{Hunt1987ASB,
  title={A single bone marrow-derived stromal cell type supports the in vitro growth of early lymphoid and myeloid cells},
  author={Pamela Hunt and D Robertson and Diane Weiss and Donna M. Rennick and Frank S. Lee and Owen N. Witte},
  journal={Cell},
  year={1987},
  volume={48},
  pages={997-1007}
}
Differentiation of Human Mast Cells from Bone‐Marrow and Cord‐Blood Progenitor Cells by Factors Produced by a Mouse Stromal Cell Line
TLDR
The culture of immunomagnetically purified human-bone-marrow- or cord-blood-derived CD34+ cells on a supportive mouse lipoblastic stromal cell line, MS-5, allows for significant amounts of highly enriched normal human mast cell populations useful for further studies on the reactivity of this cell subset.
Long-term survival of human myeloid progenitor cells induced by a mouse bone marrow stromal cell line.
Mouse endothelial-adipocyte cell line (14F1.1), which induces proliferation of mouse stem cells in culture, is also capable of supporting long-term survival in culture of human myeloid progenitor
Characterization of murine bone marrow and spleen-derived stromal cells: analysis of leukocyte marker and growth factor mRNA transcript levels.
TLDR
Results indicate that although stromal cells appear to be mesodermal in origin, they are not closely related developmentally to the hematopoietic progenitor cells they support, and suggest that they are a multifunctional component of the lymphopOietic microenvironment and may be active participants in a complex, cytokine-mediated regulatory network.
Introduction of interleukin-3 gene into stromal cells from the bone marrow alters hemopoietic differentiation but does not modify stem cell renewal.
TLDR
It is proposed that novel stromal cell factors, distinct from known CSFs, regulate stem cell renewal.
Myofibroblastic stromal cells isolated from human bone marrow induce the proliferation of both early myeloid and B-lymphoid cells.
TLDR
Normal human bone marrow stromal cells isolated from Dexter-type long-term cultures are shown to induce the proliferation of both early myeloid and B-lymphoid cells in the absence of accessory hematopoietic cells and production of IL-7 appears to be a critical parameter that determines the ability of fibroblastic-like cells to induce BCP proliferation.
Myofibroblastic stromal cells isolated from human bone marrow induce the proliferation of both early myeloid and B-lymphoid cells
TLDR
It is shown that normal human myofibroblastic BMSC induce the proliferation of both early myeloid and B-lymphoid cells in the absence of accessory hematopoietic cells.
Cytokine production and heterogeneity of primary stromal cells that support B lymphopoiesis
TLDR
The results suggest that the primary stromal cells are a distinguishable cell type but functional subsets may exist, and the primary cell phenotype appears to mirror at least one division noted among theStromal cell lines.
Interleukin-4 induces a substance in bone marrow stromal cells that reversibly inhibits factor-dependent and factor-independent cell proliferation.
TLDR
The capacity of IL-4 to induce inhibitory activity in stromal cell layers suggests that IL-2 may play a role in the regulation of hematopoiesis and partial inhibition could be achieved with pure macrophages stimulated with IL- 4 and CSF-1, suggesting that the inhibitoryActivity induced by IL-3 in mixed stroma cell layers may depend on a complex mechanism involving more than one cell type.
Native associations of early hematopoietic stem cells and stromal cells isolated in bone marrow cell aggregates.
TLDR
A scheme of stromal cell-hematopoietic cell interactions based on the cell types selectively retained within the aggregates is proposed, which presents a novel means to study in vivo stem cell-stromal cell interaction.
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