A single-blind, crossover comparison of the pharmacokinetics and cognitive effects of a new diazepam rectal gel with intravenous diazepam.

@article{Cloyd1998ASC,
  title={A single-blind, crossover comparison of the pharmacokinetics and cognitive effects of a new diazepam rectal gel with intravenous diazepam.},
  author={James C. Cloyd and Richard L. Lalonde and Thomas E. Beniak and Gary D. Novack},
  journal={Epilepsia},
  year={1998},
  volume={39 5},
  pages={
          520-6
        }
}
PURPOSE The objective of this study was to compare the pharmacokinetics and cognitive effects of a new diazepam (DZP) rectal gel (Diastat) with intravenously administered DZP. METHODS Twenty healthy volunteers were enrolled in a single-blind, randomized, double-dummy, two-period, crossover study. Subjects received either 15 mg of DZP rectal gel or 7.5 mg of DZP by intravenous infusion. Blood samples for DZP and desmethyldiazepam analysis were obtained before the dose and from 3 min to 240 h… CONTINUE READING
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