A single base pair change in proline biosynthesis genes causes osmotic stress tolerance.

@article{Dandekar1988ASB,
  title={A single base pair change in proline biosynthesis genes causes osmotic stress tolerance.},
  author={Abhaya M Dandekar and Sandra L. Uratsu},
  journal={Journal of bacteriology},
  year={1988},
  volume={170 12},
  pages={5943-5}
}
A single base pair change has been found in a site corresponding to a regulatory region of the first enzyme in the proline biosynthetic pathway. This change alters feedback inhibition and is responsible for the synthesis of high levels of proline that enable Escherichia coli to withstand osmotic stress. 

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