A single base change in the intron of a serine tRNA affects the rate of RNase P cleavage in vitro and suppressor activity in vivo in Saccharomyces cerevisiae.

@article{Willis1986ASB,
  title={A single base change in the intron of a serine tRNA affects the rate of RNase P cleavage in vitro and suppressor activity in vivo in Saccharomyces cerevisiae.},
  author={Ian Willis and D. A. Frendewey and M. Nichols and A Hottinger-Werlen and Jerome Schaack and Dieter S{\"o}ll},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 13},
  pages={5878-85}
}
Differences in the processing of dimeric tRNASer-tRNAMet precursors derived from the Schizosaccharomyces pombe sup9 wild-type and opal suppressor genes can be attributed to conformational alterations in the tRNASer anticodon/intron domain. A comparison of the patterns obtained upon transcription of the sup9+ (wild-type) and sup9-e (opal suppressor) genes in a coupled transcription/processing extract from Saccharomyces cerevisiae reveals that the latter exhibits a greatly reduced efficiency of 5… CONTINUE READING

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