A single amino acid mutation, R42A, in the Newcastle disease virus matrix protein abrogates its nuclear localization and attenuates viral replication and pathogenicity.

@article{Duan2014ASA,
  title={A single amino acid mutation, R42A, in the Newcastle disease virus matrix protein abrogates its nuclear localization and attenuates viral replication and pathogenicity.},
  author={Zhiqiang Duan and Juan Li and Jie Zhu and Jian Chen and Haixu Xu and Yuyang Wang and Huimou Liu and Shunling Hu and Xiufan Liu},
  journal={The Journal of general virology},
  year={2014},
  volume={95 Pt 5},
  pages={1067-73}
}
The Newcastle disease virus (NDV) matrix (M) protein is a highly basic and nucleocytoplasmic shuttling viral protein. Previous study has demonstrated that the N-terminal 100 aa of NDV M protein are somewhat acidic overall, but the remainder of the polypeptide is strongly basic. In this study, we investigated the role of the N-terminal basic residues in the… CONTINUE READING