A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition.

@article{Wang1995ASA,
  title={A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition.},
  author={Tza-Huei Wang and Abigail S. Hackam and William B Guggino and Garry R. Cutting},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 25},
  pages={11751-5}
}
A class of bicuculline-insensitive gamma-aminobutyric acid (GABA) receptors, GABAC, has been identified in retina. Several lines of evidence indicate that GABAC receptors are formed partially or wholly of GABA rho subunits. These receptors generate a Cl- current in response to GABA but differ from GABAA receptors in a number of ways. Picrotoxin, widely accepted as a noncompetitive antagonist of GABAA receptors, displays competitive and noncompetitive antagonism of GABAC receptors in perch and… CONTINUE READING