A single amino acid in EBNA-2 determines superior B lymphoblastoid cell line growth maintenance by Epstein-Barr virus type 1 EBNA-2.

@article{Tzellos2014ASA,
  title={A single amino acid in EBNA-2 determines superior B lymphoblastoid cell line growth maintenance by Epstein-Barr virus type 1 EBNA-2.},
  author={Stelios Tzellos and Paulo de Barros Correia and Claudio Elgueta Karstegl and Laila Cancian and Julian Cano-Flanagan and Michael J. McClellan and Michelle J West and Paul J. Farrell},
  journal={Journal of virology},
  year={2014},
  volume={88 16},
  pages={8743-53}
}
UNLABELLED Sequence differences in the EBNA-2 protein mediate the superior ability of type 1 Epstein-Barr virus (EBV) to transform human B cells into lymphoblastoid cell lines compared to that of type 2 EBV. Here we show that changing a single amino acid (S442D) from serine in type 2 EBNA-2 to the aspartate found in type 1 EBNA-2 confers a type 1 growth phenotype in a lymphoblastoid cell line growth maintenance assay. This amino acid lies in the transactivation domain of EBNA-2, and the S442D… CONTINUE READING
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