A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

@article{Lai1992ASA,
  title={A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.},
  author={Jacob S Lai and Michele A. Cleary and Winship Herr},
  journal={Genes & development},
  year={1992},
  volume={6 11},
  pages={2058-65}
}
The selective association of the herpesvirus trans-activator VP16 with the human Oct-1 homeo domain is a model for differential positive transcriptional control by homeo domains. VP16 discriminates between the closely related homeo domains of Oct-1 and Oct-2 by distinguishing among their seven amino-acid differences; these differences lie on the surface that is thought to be accessible when the homeo domain is bound to DNA. Only two of these seven differences are recognized by VP16, one in each… CONTINUE READING

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Oct - 1 and Oct - 2 : Differential transcriptional regulation by proteins that bind to the same DNA sequence

W. Herr, R. A. Sturm, +7 authors G. Ruvkun
Transcriptional regulation • 1992

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