A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity and neurovirulence of H5N1 influenza virus in mice.

@article{Zhang2012ASA,
  title={A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity and neurovirulence of H5N1 influenza virus in mice.},
  author={Yi Zhang and Yipeng Sun and Honglei Sun and Juan Pu and Yuhai Bi and Yi Shi and Xishan Lu and Jing zhou Li and Qing-yu Zhu and George F. Gao and Hanchun Yang and Jinhua Liu},
  journal={Journal of virology},
  year={2012},
  volume={86 12},
  pages={6924-31}
}
H5 influenza viruses containing a motif of multiple basic amino acids at the hemagglutinin (HA) cleavage site (HACS) are highly pathogenic in chicken but display different virulence phenotypes in mammals. Previous studies have shown that multiple basic amino acids of H5N1 influenza virus are a prerequisite for lethality in mice. However, it remains unclear which specific residue at the cleavage site affects the pathogenicity of H5N1 in mammals. A comprehensive genetic analysis of the H5N1 HACS… CONTINUE READING
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