A single IGF1 allele is a major determinant of small size in dogs.

  title={A single IGF1 allele is a major determinant of small size in dogs.},
  author={Nathan B. Sutter and Carlos Daniel Bustamante and Kevin Chase and Melissa M. Gray and Keyan Zhao and Lan Zhu and Badri K. Padhukasahasram and Eric M Karlins and Sean Davis and Paul G. Jones and Pascale Quignon and G S Johnson and Heidi G Parker and Neale Fretwell and Dana S. Mosher and Dennis F. Lawler and Ebenezer Satyaraj and Magnus Nordborg and Karl Gordon Lark and Robert K. Wayne and Elaine A Ostrander},
  volume={316 5821},
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a… CONTINUE READING
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