A single C-terminal peptide segment mediates both membrane association and localization of lysyl hydroxylase in the endoplasmic reticulum.

Abstract

Hydroxylation of lysyl residues is crucial for the unique glycosylation pattern found in collagens and for the mechanical strength of fully assembled extracellular collagen fibers. Hydroxylation is catalyzed in the lumen of the endoplasmic reticulum (ER) by a specific enzyme, lysyl hydroxylase (LH). The absence of the known ER-specific retrieval motifs in… (More)

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Cite this paper

@article{Suokas2000ASC, title={A single C-terminal peptide segment mediates both membrane association and localization of lysyl hydroxylase in the endoplasmic reticulum.}, author={Marko Suokas and Raili Myllyla and Sakari Kellokumpu}, journal={The Journal of biological chemistry}, year={2000}, volume={275 23}, pages={17863-8} }