A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia

@article{Mu2007AS2,
  title={A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia},
  author={Qiwen Mu and Kevin Johnson and Paul Simon Morgan and Emily L. Grenesko and Christine E. Molnar and Berry S. Anderson and Ziad Nahas and F. Andrew Kozel and Samet Kose and Michael B. Knable and Prabhavathi Fernandes and David E. Nichols and Richard B. Mailman and Mark S. George},
  journal={Schizophrenia Research},
  year={2007},
  volume={94},
  pages={332-341}
}

A proof-of-concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia

It is suggested that low doses of D1 agonists that do not result in measureable occupancy of the D1R do not reliably improve cognition in SCZ, unlike the observations in NHP.

Multiple dopamine receptors mediate the discriminative stimulus effects of dihydrexidine in rats

Determinations of activity at second messenger systems revealed that DHX functioned as a full agonist at D3 receptors and a partial agonists at D2 receptors in vitro, suggesting that both D1 and D2/D3 receptors mediate the discriminative stimulus effects of DHX.

Baseline Perfusion Alterations Due to Acute Application of Quetiapine and Pramipexole in Healthy Adults

It is found that quetiapine reduced perfusion in the occipital and bilateral cerebellar cortex relative to placebo and pramipexole differentially modulate regional baseline cerebral blood flow.

Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia

Pharmacokinetics of ASP4345 from Single Ascending-Dose and Multiple Ascending-Dose Phase I Studies

The pharmacokinetics of ASP4345 suggest that single daily dosing is appropriate for ASP 4345, and the concentration of AS4345 in cerebrospinal fluid compared to free drug concentrations in plasma provides evidence of penetration ofAS4345 into the brain.

Characterization of PF-6142, a Novel, Non-Catecholamine Dopamine Receptor D1 Agonist, in Murine and Nonhuman Primate Models of Dopaminergic Activation

PF-6142 improved performance in rodent models of NMDA receptor antagonist-induced cognitive dysfunction, and reversed ketamine-induced deficits in NHP performing the spatial delayed recognition task, and did not alter the efficacy of risperidone in assays predictive of antipsychotic-like effect in rodents including pre-pulse inhibition and conditioned avoidance responding.
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