A simulation test bed for hypotheses of genome evolution

  title={A simulation test bed for hypotheses of genome evolution},
  author={Robert G. Beiko and Robert L. Charlebois},
  volume={23 7},
MOTIVATION Microbial genomes undergo evolutionary processes such as gene family expansion and contraction, variable rates and patterns of sequence substitution and lateral genetic transfer. Simulation tools are essential for both the generation of data under different evolutionary models and the validation of analytical methods on such data. However, meaningful investigation of phenomena such as lateral genetic transfer requires the simultaneous consideration of many underlying evolutionary… CONTINUE READING
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Phylogenetic analyses of cyanobacterial genomes: quantification of horizontal gene transfer events

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