A simulation protocol for exercise physiology in Fontan patients using a closed loop lumped-parameter model.

  title={A simulation protocol for exercise physiology in Fontan patients using a closed loop lumped-parameter model.},
  author={Ethan Kung and Giancarlo Pennati and Francesco Migliavacca and Tain-Yen Hsia and Richard Figliola and Alison L. Marsden and A Giardini},
  journal={Journal of biomechanical engineering},
  volume={136 8}
BACKGROUND Reduced exercise capacity is nearly universal among Fontan patients, though its etiology is not yet fully understood. While previous computational studies have attempted to model Fontan exercise, they did not fully account for global physiologic mechanisms nor directly compare results against clinical and physiologic data. METHODS In this study, we developed a protocol to simulate Fontan lower-body exercise using a closed-loop lumped-parameter model describing the entire… 

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