A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob

@article{Mizuguchi2001ASS,
  title={A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob},
  author={Hiroyuki Mizuguchi and Naoya Koizumi and Tetsuji Hosono and Naoki Utoguchi and Yumiko Watanabe and Mark A. Kay and Toshiyuki Hayakawa},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={730-735}
}
The use of recombinant adenovirus (Ad) vectors containing genetically modified capsid proteins is an attractive strategy for achieving targeted gene transfer. The HI loop of the fiber knob is a promising candidate location for the incorporation of foreign ligands for achieving this goal. However, the method of constructing an Ad vector containing a foreign ligand in the HI loop of the fiber knob has proved difficult. In this study, we developed a simple system to construct fiber-modified… CONTINUE READING