A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.

Abstract

Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to… (More)

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Cite this paper

@article{Hinch2004ASL, title={A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.}, author={Robert Hinch and Joseph L. Greenstein and Antti Tanskanen and Linmiao Xu and Raimond L. Winslow}, journal={Biophysical journal}, year={2004}, volume={87 6}, pages={3723-36} }