A simplified, non-invasive fecal-based DNA integrity assay and iFOBT for colorectal cancer detection

Abstract

Neoplasia cells exfoliated from colorectal epithelium have dysfunctional apoptotic mechanisms, thus it is possible to identify high-molecular weight DNA fragments in feces. This prospective single-center study was performed to evaluate the sensitivity and specificity of fecal-based DNA integrity versus immunological fecal occult blood test (iFOBT) and… (More)
DOI: 10.1007/s00384-010-1128-x

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