A simple technique for quantitation of low levels of DNA damage in individual cells.

Abstract

Human lymphocytes were either exposed to X-irradiation (25 to 200 rads) or treated with H2O2 (9.1 to 291 microM) at 4 degrees C and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions. Both agents induced a significant increase in DNA migration, beginning at the lowest dose evaluated… (More)

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Cite this paper

@article{Singh1988AST, title={A simple technique for quantitation of low levels of DNA damage in individual cells.}, author={Narendra Singh and Michael T. Mccoy and Raymond Richard Tice and Eric L Schneider}, journal={Experimental cell research}, year={1988}, volume={175 1}, pages={184-91} }