A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC.

Abstract

[11C]Carfentanil was prepared without the need for purification by HPLC. The tetrabutylammonium salt of the precursor carboxylate was reacted with [11C]methyl triflate in DMSO. The resulting [11C]carfentanil was trapped on an Empore extraction disk and washed to remove precursor and most radioactive contaminants. The product was eluted by a small volume of ethanol, mixed with water and passed through a small column containing fibrous anion exchanger to remove remaining radioactive contaminants.

Cite this paper

@article{Jewett2001ASS, title={A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC.}, author={Douglas M Jewett}, journal={Nuclear medicine and biology}, year={2001}, volume={28 6}, pages={733-4} }