A simple synthesis of [11C]dihydrotetrabenazine (DTBZ).

  title={A simple synthesis of [11C]dihydrotetrabenazine (DTBZ).},
  author={Douglas M. Jewett and Mike R Kilbourn and Lillian C Lee},
  journal={Nuclear medicine and biology},
  volume={24 2},
[11C]Dihydrotetrabenazine (2-hydroxy-3-isobutyl-9-[11C]methoxy-10 -methoxy-1,2,3,4,6,7,- hexahydro-11bH-bezo[alpha]-quinolizine) ([11C]DTBZ) was synthesized by reacting the 9-hydroxy precursor in DMSO with gas-phase [11C]methyl iodide on a column of alumina impregnated with KOH. The reaction was instantaneous at room temperature. This column was then connected to the inlet of a short column containing basic alumina. Elution with cyclohexane removed radioactive contaminants. The radioactive… CONTINUE READING

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