A simple screening method using ion chromatography for the diagnosis of cerebral creatine deficiency syndromes

@article{Wada2011ASS,
  title={A simple screening method using ion chromatography for the diagnosis of cerebral creatine deficiency syndromes},
  author={Takahito Wada and Hiroko Shimbo and Hitoshi Osaka},
  journal={Amino Acids},
  year={2011},
  volume={43},
  pages={993-997}
}
Cerebral creatine deficiency syndromes (CCDS) are caused by genetic defects in l-arginine:glycine amidinotransferase, guanidinoacetate methyltransferase or creatine transporter 1. CCDS are characterized by abnormal concentrations of urinary creatine (CR), guanidinoacetic acid (GA), or creatinine (CN). In this study, we describe a simple HPLC method to determine the concentrations of CR, GA, and CN using a weak-acid ion chromatography column with a UV detector without any derivatization. CR, GA… CONTINUE READING