A simple ratio-based approach for power and sample size determination for 2-group comparison using Rasch models


BACKGROUND Despite the widespread use of patient-reported Outcomes (PRO) in clinical studies, their design remains a challenge. Justification of study size is hardly provided, especially when a Rasch model is planned for analysing the data in a 2-group comparison study. The classical sample size formula (CLASSIC) for comparing normally distributed endpoints… (More)
DOI: 10.1186/1471-2288-14-87

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