A simple procedure for estimating the false discovery rate

@article{Dalmasso2005ASP,
  title={A simple procedure for estimating the false discovery rate},
  author={Cyril Dalmasso and Philippe Bro{\"e}t and Thierry Moreau},
  journal={Bioinformatics},
  year={2005},
  volume={21 5},
  pages={660-8}
}
MOTIVATION The most used criterion in microarray data analysis is nowadays the false discovery rate (FDR). In the framework of estimating procedures based on the marginal distribution of the P-values without any assumption on gene expression changes, estimators of the FDR are necessarily conservatively biased. Indeed, only an upper bound estimate can be obtained for the key quantity pi0, which is the probability for a gene to be unmodified. In this paper, we propose a novel family of estimators… CONTINUE READING