A simple model framework for the prediction of controlled release from bulk eroding polymer matrices

@inproceedings{Rothstein2008ASM,
  title={A simple model framework for the prediction of controlled release from bulk eroding polymer matrices},
  author={Sam N. Rothstein and William J. Federspiel and Steven R. Little},
  year={2008}
}
A broadly applicable model for predicting controlled release could eliminate the need for exploratory, in vitro experiments during the design of new biodegradable matrix-based therapeutics. We have developed a simple mathematical model that can predict the release of many different types of agents from bulk eroding polymer matrices without regression. New methods for deterministically calculating the magnitude of the initial burst and the duration of the lag phase (time before Fickian release… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Mathematical modeling of polymer erosion: consequences for drug delivery.

  • International journal of pharmaceutics
  • 2011
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Ignoring the modeling approaches: Towards the shadowy paths in nanomedicine.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND