A simple model framework for the prediction of controlled release from bulk eroding polymer matrices

@article{Rothstein2008ASM,
  title={A simple model framework for the prediction of controlled release from bulk eroding polymer matrices},
  author={Sam N. Rothstein and W. Federspiel and S. Little},
  journal={Journal of Materials Chemistry},
  year={2008},
  volume={18},
  pages={1873-1880}
}
  • Sam N. Rothstein, W. Federspiel, S. Little
  • Published 2008
  • Materials Science
  • Journal of Materials Chemistry
  • A broadly applicable model for predicting controlled release could eliminate the need for exploratory, in vitro experiments during the design of new biodegradable matrix-based therapeutics. We have developed a simple mathematical model that can predict the release of many different types of agents from bulk eroding polymer matrices without regression. New methods for deterministically calculating the magnitude of the initial burst and the duration of the lag phase (time before Fickian release… CONTINUE READING
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