A simple model for understanding the origin of the amide proton transfer MRI signal in tissue.

@article{Zhou2012ASM,
  title={A simple model for understanding the origin of the amide proton transfer MRI signal in tissue.},
  author={Jinyuan Zhou and Kun Yan and He Zhu},
  journal={Applied magnetic resonance},
  year={2012},
  volume={42 3},
  pages={393-402}
}
Amide proton transfer (APT) imaging is a new molecular MRI technique that gives contrast at the cellular protein level. To better understand the origin of the APT signal in tissue, fresh and cooked hen eggs (n = 4) were imaged at 4.7 Tesla. The APT effect was quantified using the asymmetry in the magnetization transfer ratio (MTR(asym)) at the composite amide proton resonance frequency (3.5 ppm from the water resonance). The measured APT signals were significantly higher in the fresh egg white… CONTINUE READING

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