A simple method for the analysis by MS/MS of underivatized amino acids on dry blood spots from newborn screening

Abstract

The analysis by electrospray-ionization tandem mass spectrometry of amino acids with butyl esterification and isotopically labeled internal standard is routine in newborn screening laboratories worldwide. In the present study, we established a direct analysis method of higher accuracy that uses a non-deuterated internal standard. The automatic sampler and… (More)
DOI: 10.1007/s00726-011-0910-6

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