A simple method for stem cell labeling with fluorine 18.

  title={A simple method for stem cell labeling with fluorine 18.},
  author={Bing Ma and Kurt D. Hankenson and James E Dennis and Arnold I Caplan and Steven A. N. Goldstein and Michael R. Kilbourn},
  journal={Nuclear medicine and biology},
  volume={32 7},
Hexadecyl-4-[(18)F]fluorobenzoate ([(18)F]HFB), a long chain fluorinated benzoic acid ester, was prepared in a one-step synthesis by aromatic nucleophilic substitution of [(18)F]fluoride ion on hexadecyl-4-(N,N,N-trimethylammonio)benzoate. The radiolabeled ester was obtained in good yields (52% decay corrected) and high purity (97%). [(18)F]HFB was used to radiolabel rat mesenchymal stem cells (MSCs) by absorption into cell membranes. MicroPET imaging of [(18)F]HFB-labeled MSCs following… CONTINUE READING

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