A simple method for screening monoamine oxidase (MAO) inhibitory drugs for type preference.

  • R L Dorris
  • Published 1982 in Journal of pharmacological methods


A simple method is described for screening monoamine oxidase (MAO) inhibitors for preferential action on either type A or type B MAO. Kynuramine, a substrate for both types of MAO, was used and the sources of enzyme were rat heart (type A) and mouse heart (type B). The method clearly showed that clorgyline (a preferential type A inhibitor) preferentially… (More)