A simple method for gene expression and chromatin profiling of individual cell types within a tissue.

@article{Deal2010ASM,
  title={A simple method for gene expression and chromatin profiling of individual cell types within a tissue.},
  author={Roger B Deal and Steven Henikoff},
  journal={Developmental cell},
  year={2010},
  volume={18 6},
  pages={1030-40}
}
Understanding the production and function of specialized cells during development requires the isolation of individual cell types for analysis, but this is currently a major technical challenge. Here we describe a method for cell type-specific RNA and chromatin profiling that circumvents many of the limitations of current methods for cell isolation. We used in vivo biotin labeling of a nuclear envelope protein in individual cell types followed by affinity isolation of labeled nuclei to measure… CONTINUE READING
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