A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

  title={A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences},
  author={Motoo Kimura},
  journal={Journal of Molecular Evolution},
  • M. Kimura
  • Published 1 December 1980
  • Biology
  • Journal of Molecular Evolution
SummarySome simple formulae were obtained which enable us to estimate evolutionary distances in terms of the number of nucleotide substitutions (and, also, the evolutionary rates when the divergence times are known). In comparing a pair of nucleotide sequences, we distinguish two types of differences; if homologous sites are occupied by different nucleotide bases but both are purines or both pyrimidines, the difference is called type I (or “transition” type), while, if one of the two is a… 

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