A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

@article{Kimura2005ASM,
  title={A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences},
  author={M. Kimura},
  journal={Journal of Molecular Evolution},
  year={2005},
  volume={16},
  pages={111-120}
}
  • M. Kimura
  • Published 2005
  • Biology, Medicine
  • Journal of Molecular Evolution
  • SummarySome simple formulae were obtained which enable us to estimate evolutionary distances in terms of the number of nucleotide substitutions (and, also, the evolutionary rates when the divergence times are known). In comparing a pair of nucleotide sequences, we distinguish two types of differences; if homologous sites are occupied by different nucleotide bases but both are purines or both pyrimidines, the difference is called type I (or “transition” type), while, if one of the two is a… CONTINUE READING
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