A simple method for determining the optimal dosage of progestin in postmenopausal women receiving estrogens.

@article{Padwick1986ASM,
  title={A simple method for determining the optimal dosage of progestin in postmenopausal women receiving estrogens.},
  author={Malcolm L. Padwick and John Pryse-Davies and MalcolmI. Whitehead},
  journal={The New England journal of medicine},
  year={1986},
  volume={315 15},
  pages={
          930-4
        }
}
Progestin is often added to regimens of estrogen therapy in postmenopausal women to reduce the risk of endometrial hyperstimulation, but it may cause undesirable metabolic effects. Therefore, a low dosage is recommended. At present, the only way to determine whether the dosage of progestin is causing the desired secretory transformation of the endometrium is by endometrial sampling, which is invasive. We studied 102 postmenopausal women undergoing estrogen therapy who also took a progestin for… CONTINUE READING
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