A simple mass-action model for the eukaryotic heat shock response and its mathematical validation

  title={A simple mass-action model for the eukaryotic heat shock response and its mathematical validation},
  author={I. Petre and A. Mizera and Claire L. Hyder and Annika Meinander and A. Mikhailov and R. Morimoto and L. Sistonen and J. Eriksson and R. Back},
  journal={Natural Computing},
  • I. Petre, A. Mizera, +6 authors R. Back
  • Published 2010
  • Physics, Computer Science
  • Natural Computing
  • The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on… CONTINUE READING
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