A simple implementation of a normal mixture approach to differential gene expression in multiclass microarrays
@article{McLachlan2006ASI, title={A simple implementation of a normal mixture approach to differential gene expression in multiclass microarrays}, author={G. McLachlan and Richard Bean and L. B. Jones}, journal={Bioinformatics}, year={2006}, volume={22 13}, pages={ 1608-15 } }
MOTIVATION
An important problem in microarray experiments is the detection of genes that are differentially expressed in a given number of classes. We provide a straightforward and easily implemented method for estimating the posterior probability that an individual gene is null. The problem can be expressed in a two-component mixture framework, using an empirical Bayes approach. Current methods of implementing this approach either have some limitations due to the minimal assumptions made or… CONTINUE READING
163 Citations
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