• Mathematics, Computer Science, Medicine
• Published in Bioinformatics 2006
• DOI:10.1093/bioinformatics/btl148

A simple implementation of a normal mixture approach to differential gene expression in multiclass microarrays

@article{McLachlan2006ASI,
  title={A simple implementation of a normal mixture approach to differential gene expression in multiclass microarrays},
  author={Geoffrey J. McLachlan and Richard Bean and Liat Ben-Tovim Jones},
  journal={Bioinformatics},
  year={2006},
  volume={22 13},
  pages={
          1608-15
        }
}

• Geoffrey J. McLachlan, Richard Bean, Liat Ben-Tovim Jones

MOTIVATION An important problem in microarray experiments is the detection of genes that are differentially expressed in a given number of classes. We provide a straightforward and easily implemented method for estimating the posterior probability that an individual gene is null. The problem can be expressed in a two-component mixture framework, using an empirical Bayes approach. Current methods of implementing this approach either have some limitations due to the minimal assumptions made or… CONTINUE READING

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