A simple implementation of a normal mixture approach to differential gene expression in multiclass microarrays

  title={A simple implementation of a normal mixture approach to differential gene expression in multiclass microarrays},
  author={G. McLachlan and Richard Bean and L. B. Jones},
  volume={22 13},
  • G. McLachlan, Richard Bean, L. B. Jones
  • Published 2006
  • Computer Science, Medicine
  • Bioinformatics
  • MOTIVATION An important problem in microarray experiments is the detection of genes that are differentially expressed in a given number of classes. We provide a straightforward and easily implemented method for estimating the posterior probability that an individual gene is null. The problem can be expressed in a two-component mixture framework, using an empirical Bayes approach. Current methods of implementing this approach either have some limitations due to the minimal assumptions made or… CONTINUE READING
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