A simple genetic basis for a complex psychological trait in laboratory mice.

  title={A simple genetic basis for a complex psychological trait in laboratory mice.},
  author={Jonathan Flint and Robin Corley and John C Defries and David W. Fulker and John R. Gray and Samantha K Miller and Allan C. Collins},
  volume={269 5229},
Psychological traits are commonly inferred from covariation in sets of behavioral measures that otherwise appear to have little in common. Emotionality in mice is such a trait, defined here by covariation in activity and defecation in a novel environment and emergence into the open arms of an elevated plus maze. Behavioral and quantitative trait analyses were conducted on four measures obtained from 879 mice from an F2 intercross. Three loci, on murine chromosomes 1, 12, and 15, were mapped… CONTINUE READING
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