A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease.

@article{Alper2000ASE,
  title={A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease.},
  author={Chester A. Alper and D. P. Dubey and Edmond J. Yunis and Zuheir L. Awdeh},
  journal={Experimental and clinical immunogenetics},
  year={2000},
  volume={17 3},
  pages={138-47}
}
We wished to determine the frequencies of the MHC and non-MHC susceptibility genes for polygenic autoimmune diseases like type 1 diabetes (IDDM). We used Mendelian inheritance and the Hardy-Weinberg equilibrium to calculate the frequencies of mating pairs and susceptible offspring under classical recessive and dominant inheritance of the MHC susceptibility gene. We then analyzed the distribution of haplotype sharing by affected sib pairs of the 4 MHC haplotypes in each of the kinds of mating… CONTINUE READING