A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS.

@article{Berm2015ASD,
  title={A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS.},
  author={Elizabeth J. J. Berm and Jolanda Paardekooper and E Brummel-Mulder and Eelko Hak and Bob Wilffert and Jan Gerard Maring},
  journal={Talanta},
  year={2015},
  volume={134},
  pages={165-172}
}
Therapeutic drug monitoring (TDM) of tricyclic antidepressants (TCAs) is considered useful in patients with major depressive disorder, since these drugs display large individual differences in clearance, and the therapeutic windows of these drugs are relatively small. We developed an assay for determination of amitriptyline (ATP), nortriptyline (NTP), imipramine (IMP), desipramine (DSP) clomipramine (CMP) and desmethyl-clomipramine (DCMP) in dried blood spots (DBS). A fast and robust LC-MS/MS… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Dried Blood Spot sampling in psychiatry: Perspectives for improving therapeutic drug monitoring.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology • 2017
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 38 references

A simple bioanalytical method for the quantification of antiepileptic drugs in dried blood spots.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…