A simple dried blood spot method for clinical pharmacological analyses of etoposide in cancer patients using liquid chromatography and fluorescence detection.

@article{Kukec2016ASD,
  title={A simple dried blood spot method for clinical pharmacological analyses of etoposide in cancer patients using liquid chromatography and fluorescence detection.},
  author={Renata Re{\vz}onja Kukec and I. Grabnar and Ale{\vs} Mrhar and Nan{\vc}a {\vC}ebron Lipovec and Tanja {\vC}ufer and Toma{\vz} Vovk},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2016},
  volume={452},
  pages={99-105}
}
BACKGROUND Therapeutic drug monitoring of etoposide is not part of the routine clinical practice, however, measuring etoposide plasma concentration may be useful to prevent chemotherapy related adverse drug reactions. This paper describes the development and validation of a dried blood spot (DBS) assay for the determination of etoposide in blood samples of lung cancer patients. METHODS The whole blood spot was cut out of the DBS card followed by sonication assisted liquid drug extraction… CONTINUE READING