A simple displacement aptamer assay on resistive pulse sensor for small molecule detection.

@article{Maugi2021ASD,
  title={A simple displacement aptamer assay on resistive pulse sensor for small molecule detection.},
  author={Rushabh Maugi and Bernadette Gamble and David Bunka and Mark Platt},
  journal={Talanta},
  year={2021},
  volume={225},
  pages={
          122068
        }
}
A universal aptamer-based sensing strategy is proposed using DNA modified nanocarriers and Resistive Pulse Sensing (RPS) for the rapid (≤20 min) and label free detection of small molecules. The surface of a magnetic nanocarrier was first modified with a ssDNA (anchor) which is designed to be partially complimentary in sequence to the ssDNA aptamer. The aptamer and anchor form a stable dsDNA complex on the nanocarriers surface. Upon the addition of the target molecule, a conformational change… 
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