A simple depletion model of the readily releasable pool of synaptic vesicles cannot account for paired-pulse depression.

@article{Sullivan2007ASD,
  title={A simple depletion model of the readily releasable pool of synaptic vesicles cannot account for paired-pulse depression.},
  author={Jane M. Sullivan},
  journal={Journal of neurophysiology},
  year={2007},
  volume={97 1},
  pages={948-50}
}
Paired-pulse depression (PPD) is a form of short-term plasticity that plays a central role in processing of synaptic activity and is manifest as a decrease in the size of the response to the second of two closely timed stimuli. Despite mounting evidence to the contrary, PPD is still commonly thought to reflect depletion of the pool of synaptic vesicles available for release in response to the second stimulus. Here it is shown that PPD cannot be accounted for by depletion at excitatory synapses… CONTINUE READING
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