A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells.

@article{Maruotti2013ASA,
  title={A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells.},
  author={Julien A. Maruotti and Karl J. Wahlin and David Gorrell and Imran Ahmed Bhutto and Gerard A. Lutty and Donald J. Zack},
  journal={Stem cells translational medicine},
  year={2013},
  volume={2 5},
  pages={341-54}
}
Age-related macular degeneration (AMD), the leading cause of irreversible vision loss and blindness among the elderly in industrialized countries, is associated with the dysfunction and death of the retinal pigment epithelial (RPE) cells. As a result, there has been significant interest in developing RPE culture systems both to study AMD disease mechanisms and to provide substrate for possible cell-based therapies. Because of their indefinite self-renewal, human pluripotent stem cells (hPSCs… CONTINUE READING
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