A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma--application to preclinical pharmacokinetics.

@article{Pathak2008ASA,
  title={A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma--application to preclinical pharmacokinetics.},
  author={Shriram M Pathak and Averineni Ranjith Kumar and Prashant B. Musmade and Nayanabhirama Udupa},
  journal={Talanta},
  year={2008},
  volume={76 2},
  pages={338-46}
}
A sensitive high performance liquid chromatographic (HPLC) method involving fluorescence detection was developed for the determination of fexofenadine (FEX), known to have low oral bioavailability, in rat plasma. In order to understand the effect of various chromatographic factors on the separation of analytes and to simultaneously optimize the resolution and analysis run time, a response surface method was used. The chromatographic separation was achieved using a Supelco C(18)-DB (250 mm x 4… CONTINUE READING

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