A simple and efficient method to visualize and quantify the efficiency of chromosomal mutations from genome editing

Abstract

Genome editing with designer nucleases such as TALEN and CRISPR/Cas enzymes has broad applications. Delivery of these designer nucleases into organisms induces various genetic mutations including deletions, insertions and nucleotide substitutions. Characterizing those mutations is critical for evaluating the efficacy and specificity of targeted genome… (More)
DOI: 10.1038/srep35488

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