A simple HPLC method for the determination of bifendate: application to a pharmacokinetic study of bifendate liposome.

@article{Chen2007ASH,
  title={A simple HPLC method for the determination of bifendate: application to a pharmacokinetic study of bifendate liposome.},
  author={Zhi-peng Chen and Jia-bi Zhu and Hong-xuan Chen and Yan-yu Xiao},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2007},
  volume={857 2},
  pages={246-50}
}
A rapid, sensitive and simple high-performance liquid chromatographic (HPLC) method with ultraviolet detector (UV) has been developed for the determination of bifendate in 100 microl plasma of rats. Sample preparation was carried out by deproteinization with 100 microl of acetonitrile. A 20 microl of supernatant was directly injected into the HPLC system with methanol-double distilled water (65/35, v/v) as the mobile phase at a flow rate of 1.0 ml/min. Separation was performed with a… CONTINUE READING