A simple HPLC method for simultaneous determination of lopinavir, ritonavir and efavirenz.

@article{Usami2003ASH,
  title={A simple HPLC method for simultaneous determination of lopinavir, ritonavir and efavirenz.},
  author={Yoshiko Usami and Tsuyoshi Oki and Masahiko Nakai and Masafumi Sagisaka and Tsuguhiro Kaneda},
  journal={Chemical & pharmaceutical bulletin},
  year={2003},
  volume={51 6},
  pages={715-8}
}
We developed a simple HPLC method for the simultaneous determination of lopinavir (LPV), ritonavir (RTV) and efavirenz (EFV) to evaluate the efficiency of co-administration of LPV/RTV and EFV in Japanese patients enrolled in a clinical study. The monitoring of LPV plasma concentration is important because co-administration of LPV/RTV with EFV sometimes decreases plasma concentrations of LPV caused by EFV activation of cytochrome P-450 3A. A solution of acetonitrile, methanol and… CONTINUE READING

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