A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants.

Abstract

A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are… (More)
DOI: 10.1021/jo801501e

Topics

2 Figures and Tables

Cite this paper

@article{Nara2008ASC, title={A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants.}, author={Susheel J. Nara and Mukund Jha and Johan Brinkhorst and Tony J Zemanek and Derek A Pratt}, journal={The Journal of organic chemistry}, year={2008}, volume={73 23}, pages={9326-33} }